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Volume 196, 2017
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Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

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Abstract

Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

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Publication details

The article was received on 24 Jun 2016, accepted on 05 Sep 2016 and first published on 05 Sep 2016


Article type: Paper
DOI: 10.1039/C6FD00153J
Citation: Faraday Discuss., 2017,196, 351-362
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    Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

    T. Chen, N. Xie, L. Viglianti, Y. Zhou, H. Tan, B. Z. Tang and Y. Tang, Faraday Discuss., 2017, 196, 351
    DOI: 10.1039/C6FD00153J

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