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Volume 195, 2016
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Proton-coupled electron transfer reactions: analytical rate constants and case study of kinetic isotope effects in lipoxygenase

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Abstract

A general theory has been developed for proton-coupled electron transfer (PCET), which is vital to a wide range of chemical and biological processes. This theory describes PCET reactions in terms of nonadiabatic transitions between reactant and product electron–proton vibronic states and includes the effects of thermal fluctuations of the solvent or protein environment, as well as the proton donor–acceptor motion. Within the framework of this general PCET theory, a series of analytical rate constant expressions has been derived for PCET reactions in well-defined regimes. Herein, the application of this theory to PCET in the enzyme soybean lipoxygenase illustrates the regimes of validity for the various rate constant expressions and elucidates the fundamental physical principles dictating PCET reactions. Such theoretical studies provide significant physical insights that guide the interpretation of experimental data and lead to experimentally testable predictions. A combination of theoretical treatments with atomic-level simulations is essential to understanding PCET.

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Publication details

The article was received on 09 May 2016, accepted on 07 Jun 2016 and first published on 07 Jun 2016


Article type: Paper
DOI: 10.1039/C6FD00122J
Citation: Faraday Discuss., 2016,195, 171-189
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    Proton-coupled electron transfer reactions: analytical rate constants and case study of kinetic isotope effects in lipoxygenase

    A. V. Soudackov and S. Hammes-Schiffer, Faraday Discuss., 2016, 195, 171
    DOI: 10.1039/C6FD00122J

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