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Issue 2, 2016
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Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

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Abstract

The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+ and causing a differential impact on cytotoxicity.

Graphical abstract: Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

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Publication details

The article was received on 02 Dec 2015, accepted on 22 Feb 2016 and first published on 24 Feb 2016


Article type: Paper
DOI: 10.1039/C5EN00271K
Citation: Environ. Sci.: Nano, 2016,3, 365-374
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    Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

    A. Wongrakpanich, I. A. Mudunkotuwa, S. M. Geary, A. S. Morris, K. A. Mapuskar, D. R. Spitz, V. H. Grassian and A. K. Salem, Environ. Sci.: Nano, 2016, 3, 365
    DOI: 10.1039/C5EN00271K

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