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Issue 45, 2016
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CO-releasing molecule (CORM) conjugate systems

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Abstract

The development of CORMs (CO-releasing molecules) as a prodrug for CO administration in living organisms has attracted significant attention. CORMs offer the promising possibility of a safe and controllable release of CO in low amounts triggered by light, ligands, enzymes, etc. For the targeting of specific tissues or diseases and to prevent possible side effects from metals and other residues after CO release, these CORMs are attached to biocompatible systems, like peptides, polymers, nanoparticles, dendrimers, protein cages, non-wovens, tablets, and metal–organic frameworks. We discuss in this review the known CORM carrier conjugates, in short CORM conjugates, with covalently-bound or incorporated CORMs for medicinal and therapeutic applications. Most conjugates are nontoxic, show increasing half-lives of CO release, and make use of the EPR-effect, but still show problems because of a continuous background of CO release and the absence of an on/off-switch for the CO release.

Graphical abstract: CO-releasing molecule (CORM) conjugate systems

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Publication details

The article was received on 09 Sep 2016, accepted on 17 Oct 2016 and first published on 18 Oct 2016


Article type: Perspective
DOI: 10.1039/C6DT03515A
Citation: Dalton Trans., 2016,45, 18045-18063
  • Open access: Creative Commons BY-NC license
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    CO-releasing molecule (CORM) conjugate systems

    A. C. Kautz, P. C. Kunz and C. Janiak, Dalton Trans., 2016, 45, 18045
    DOI: 10.1039/C6DT03515A

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