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Issue 45, 2016
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A lipophilic copper(II) complex as an optical probe for intracellular detection of NO

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Abstract

A new chemical sensor for cellular imaging of NO is presented. This cell-permeable probe is based on a complex where copper(II) is coordinated to a tridentate ligand substituted with a fluorophore (NBD) and an octyl group. The fluorescence response of this complex towards a range of reactive species (namely NO, NO2, NO3, H2O2, ClO, O2 and ONOO) has been studied in vitro showing that the probe is highly selective for NO. The probe is readily taken up by cells and is able to image the cellular concentrations of NO.

Graphical abstract: A lipophilic copper(ii) complex as an optical probe for intracellular detection of NO

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Publication details

The article was received on 20 Jul 2016, accepted on 12 Oct 2016 and first published on 18 Oct 2016


Article type: Paper
DOI: 10.1039/C6DT02880B
Citation: Dalton Trans., 2016,45, 18177-18182
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    A lipophilic copper(II) complex as an optical probe for intracellular detection of NO

    N. Wilson, L. H. Mak, A. Cilibrizzi, A. D. Gee, N. J. Long, R. Woscholski and R. Vilar, Dalton Trans., 2016, 45, 18177
    DOI: 10.1039/C6DT02880B

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