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Issue 44, 2016
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Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes

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Abstract

Diagnosis by MRI is frequently non-trivial due to the low sensitivity of the technique. Signal enhancing contrast agents (CAs) are used to aid in the analysis of MR images. We present here a simple protocol for the preparation of responsive CAs based on Mn nanosheets. Mn nanostructures presented here undergo a chemical and structural change in the presence of altered physiological conditions that activate their signal. This strategy allows for a reduction of background, increasing the sensitivity of the technique. The simple synthetic protocol followed allows for the combination of the nanosheets with reporter molecules for other imaging techniques, like carbon quantum dots for optical imaging.

Graphical abstract: Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes

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Publication details

The article was received on 18 Jul 2016, accepted on 05 Oct 2016 and first published on 06 Oct 2016


Article type: Paper
DOI: 10.1039/C6DT02840C
Citation: Dalton Trans., 2016,45, 17672-17680
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    Green synthesis of multimodal ‘OFF–ON’ activatable MRI/optical probes

    J. Gallo, N. Vasimalai, M. T. Fernandez-Arguelles and M. Bañobre-López, Dalton Trans., 2016, 45, 17672
    DOI: 10.1039/C6DT02840C

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