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Issue 47, 2016
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Platinum(II) O,S complexes as potential metallodrugs against Cisplatin resistance

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Abstract

We report on platinum(II) complexes with different cinnamic acid derivatives as ligands with cytotoxic activity against Cisplatin resistant ovarian cancer cell line subcultures of SKOV3 and A2780. A typical mechanism of action for platinum(II) complexes as Cisplatin itself is binding to the DNA and inducing double-strand breaks. We examined the biological behavior of these potential drugs with 9-methylguanine using NMR spectroscopic methods and their DNA damage potential including γH2AX-foci analyses. X-ray diffraction methods have been used to elucidate the molecular structures of the platinum(II) complexes. Interactions with the model protein lysozyme have been evaluated by different techniques including UV-Vis absorption spectroscopy, fluorescence and X-ray crystallography.

Graphical abstract: Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance

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Publication details

The article was received on 10 Apr 2016, accepted on 10 Aug 2016 and first published on 11 Aug 2016


Article type: Paper
DOI: 10.1039/C6DT01388K
Citation: Dalton Trans., 2016,45, 18876-18891
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    Platinum(II) O,S complexes as potential metallodrugs against Cisplatin resistance

    J. Hildebrandt, N. Häfner, H. Görls, D. Kritsch, G. Ferraro, M. Dürst, I. B. Runnebaum, A. Merlino and W. Weigand, Dalton Trans., 2016, 45, 18876
    DOI: 10.1039/C6DT01388K

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