Jump to main content
Jump to site search

Issue 16, 2016
Previous Article Next Article

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

Author affiliations

Abstract

Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.

Graphical abstract: Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Jan 2016, accepted on 16 Feb 2016 and first published on 17 Feb 2016


Article type: Communication
DOI: 10.1039/C6DT00186F
Citation: Dalton Trans., 2016,45, 6812-6815
  •   Request permissions

    Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

    Stephanie. J. Lucas, R. M. Lord, A. M. Basri, S. J. Allison, R. M. Phillips, A. J. Blacker and P. C. McGowan, Dalton Trans., 2016, 45, 6812
    DOI: 10.1039/C6DT00186F

Search articles by author

Spotlight

Advertisements