Jump to main content
Jump to site search

Issue 22, 2016
Previous Article Next Article

A general protocol for the reductive N-methylation of amines using dimethyl carbonate and molecular hydrogen: mechanistic insights and kinetic studies

Author affiliations

Abstract

Herein, we report for the first time a general and selective ruthenium-catalyzed reductive methylation of amines using dimethyl carbonate as a C1 source and molecular hydrogen as a reducing agent. Notably, this methodology allows N-methylated tertiary aromatic and aliphatic amines to be obtained with good to excellent yields using a green, non-toxic and biodegradable carbon source in the presence of an in situ formed Ru/Triphos complex. The catalytic protocol presented here opens the possibility of developing new sustainable processes for the selective synthesis of N-methyl substituted amines using molecular hydrogen. Mechanistic and kinetic studies have been carried out in order to understand the pathways involved in the general reaction mechanism for the N-methylation of aniline.

Graphical abstract: A general protocol for the reductive N-methylation of amines using dimethyl carbonate and molecular hydrogen: mechanistic insights and kinetic studies

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 29 Jun 2016, accepted on 14 Sep 2016 and first published on 11 Oct 2016


Article type: Paper
DOI: 10.1039/C6CY01401A
Citation: Catal. Sci. Technol., 2016,6, 7956-7966
  •   Request permissions

    A general protocol for the reductive N-methylation of amines using dimethyl carbonate and molecular hydrogen: mechanistic insights and kinetic studies

    J. R. Cabrero-Antonino, R. Adam, K. Junge and M. Beller, Catal. Sci. Technol., 2016, 6, 7956
    DOI: 10.1039/C6CY01401A

Search articles by author