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Issue 21, 2016
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Polypeptide self-assemblies: nanostructures and bioapplications

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Abstract

Polypeptide copolymers can self-assemble into diverse aggregates. The morphology and structure of aggregates can be varied by changing molecular architectures, self-assembling conditions, and introducing secondary components such as polymers and nanoparticles. Polypeptide self-assemblies have gained significant attention because of their potential applications as delivery vehicles for therapeutic payloads and as additives in the biomimetic mineralization of inorganics. This review article provides an overview of recent advances in nanostructures and bioapplications related to polypeptide self-assemblies. We highlight recent contributions to developing strategies for the construction of polypeptide assemblies with increasing complexity and novel functionality that are suitable for bioapplications. The relationship between the structure and properties of the polypeptide aggregates is emphasized. Finally, we briefly outline our perspectives and discuss the challenges in the field.

Graphical abstract: Polypeptide self-assemblies: nanostructures and bioapplications

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Publication details

The article was received on 07 Jan 2016, published on 09 Sep 2016 and first published online on 09 Sep 2016


Article type: Review Article
DOI: 10.1039/C6CS00013D
Citation: Chem. Soc. Rev., 2016,45, 5985-6012
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    Polypeptide self-assemblies: nanostructures and bioapplications

    C. Cai, J. Lin, Y. Lu, Q. Zhang and L. Wang, Chem. Soc. Rev., 2016, 45, 5985
    DOI: 10.1039/C6CS00013D

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