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Issue 6, 2016
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Cascade polycyclizations in natural product synthesis

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Abstract

Cascade (domino) reactions have an unparalleled ability to generate molecular complexity from relatively simple starting materials; these transformations are particularly appealing when multiple rings are forged during this process. In this tutorial review, we cover recent highlights in cascade polycyclizations as applied to natural product synthesis, including pericyclic, heteroatom-mediated, cationic, metal-catalyzed, organocatalytic, and radical sequences.

Graphical abstract: Cascade polycyclizations in natural product synthesis

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Publication details

The article was received on 03 Feb 2015 and first published on 21 Jan 2016


Article type: Tutorial Review
DOI: 10.1039/C5CS00105F
Citation: Chem. Soc. Rev., 2016,45, 1557-1569
  • Open access: Creative Commons BY license
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    Cascade polycyclizations in natural product synthesis

    R. Ardkhean, D. F. J. Caputo, S. M. Morrow, H. Shi, Y. Xiong and E. A. Anderson, Chem. Soc. Rev., 2016, 45, 1557
    DOI: 10.1039/C5CS00105F

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