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Issue 20, 2016
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Organocatalytic enantioselective desymmetrisation

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Abstract

Organocatalytic enantioselective desymmetrisation of achiral or meso compounds is a powerful strategy for the construction of enantiomerically enriched complex molecules, often with multiple stereocentres and in high selectivities. Recent years have seen increasing use of organocatalysts in desymmetrisation methodology, in contrast to traditional metal- or enzyme-catalysed reactions, with many impressive advances made in the current decade. This review will provide an overview of the field since 2010, with the aim of highlighting both the practical applications and elegance of enantioselective desymmetrisation to the wider synthetic community.

Graphical abstract: Organocatalytic enantioselective desymmetrisation

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Publication details

The article was received on 11 Mar 2016 and first published on 27 Jun 2016


Article type: Review Article
DOI: 10.1039/C5CS00015G
Citation: Chem. Soc. Rev., 2016,45, 5474-5540
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    Organocatalytic enantioselective desymmetrisation

    A. Borissov, T. Q. Davies, S. R. Ellis, T. A. Fleming, M. S. W. Richardson and D. J. Dixon, Chem. Soc. Rev., 2016, 45, 5474
    DOI: 10.1039/C5CS00015G

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