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Issue 46, 2016
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Nanoscale hydration dynamics of DNA–lipid blend dry films: DNA-size dependency

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Abstract

In this study, nanoscale hydration dynamics of DNA–lipid blend dry films are investigated via small angle X-ray diffraction. Compared to the hydration of lipid films, fragmented short DNA strands and counterions in stacked lipid layers dramatically accelerate both the relaxation of the lamellar distance to a metastable interval and the subsequent peeling-off process of lipid bilayers. Moreover, genome-sized long DNA and counterions accelerate the relaxation process, but suppress the peeling-off process and simultaneously induce a damped-oscillation of the lamellar interval; this is probably due to the viscoelastic properties of the entangled long DNA dissolved in hydrated water between the stacked lipid bilayers. This study's findings can pave the way for producing cell-sized liposomes, which efficiently encapsulate any arbitrary sized DNA through natural swelling.

Graphical abstract: Nanoscale hydration dynamics of DNA–lipid blend dry films: DNA-size dependency

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Publication details

The article was received on 13 Sep 2016, accepted on 27 Oct 2016 and first published on 28 Oct 2016


Article type: Paper
DOI: 10.1039/C6CP06305E
Citation: Phys. Chem. Chem. Phys., 2016,18, 31664-31669
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    Nanoscale hydration dynamics of DNA–lipid blend dry films: DNA-size dependency

    S. F. Shimobayashi, M. Hishida, T. Kurimura and M. Ichikawa, Phys. Chem. Chem. Phys., 2016, 18, 31664
    DOI: 10.1039/C6CP06305E

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