Jump to main content
Jump to site search

Issue 43, 2016
Previous Article Next Article

Time-gated luminescence bioimaging with new luminescent nanocolloids based on [Mo6I8(C2F5COO)6]2− metal atom clusters

Author affiliations

Abstract

Bioimaging and cell labeling using red or near infrared phosphors emitting in the “therapeutic window” of biological tissues have recently become some of the most active research fields in modern medical diagnostics. However, because organic and inorganic autofluorophores are omnipresent in nature, very often the background signal from fluorochromes other than targeted probes has to be eliminated. This discrimination could be available using a time-gated luminescence microscopy (TGLM) technique associated with long lifetime phosphorescent nanocomposites. Here, we report new SiO2 nanostructured particle (50 nm in diameter) embedded luminescent nanosized [Mo6I8(C2F5COO)6]2− metal atom clusters (1 nm in diameter), successfully prepared by the microemulsion technique. This combination provides new physical insight and displays red emission in biological based solution under UV-Vis excitation with long lifetimes of around 17 and 84 μs. Moreover, the nanoparticles can be internalized by cancer cells after surface functionalization by transferrin protein and clearly imaged by TGLM under excitation at 365 nm. The nanocomposites have been mainly characterized by scanning and transmission electron microscopies (SEM and HAADF-STEM), UV-Vis and photoluminescence (PL) spectroscopies.

Graphical abstract: Time-gated luminescence bioimaging with new luminescent nanocolloids based on [Mo6I8(C2F5COO)6]2− metal atom clusters

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 30 Jul 2016, accepted on 07 Oct 2016 and first published on 07 Oct 2016


Article type: Paper
DOI: 10.1039/C6CP05290H
Citation: Phys. Chem. Chem. Phys., 2016,18, 30166-30173
  •   Request permissions

    Time-gated luminescence bioimaging with new luminescent nanocolloids based on [Mo6I8(C2F5COO)6]2− metal atom clusters

    C. Neaime, M. Amela-Cortes, F. Grasset, Y. Molard, S. Cordier, B. Dierre, M. Mortier, T. Takei, K. Takahashi, H. Haneda, M. Verelst and S. Lechevallier, Phys. Chem. Chem. Phys., 2016, 18, 30166
    DOI: 10.1039/C6CP05290H

Search articles by author