Jump to main content
Jump to site search

Issue 34, 2016
Previous Article Next Article

Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

Author affiliations

Abstract

GTX1/4 can induce the formation of an antiparallel G-quadruplex structure in aptamer GO18-T-d and combine steadily in the groove at the top of the G-quadruplex structure. The complex structures and special induced fit mechanism between aptamer and small molecules provide a reference for aptamer development in molecular diagnostics and therapeutic application.

Graphical abstract: Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Feb 2016, accepted on 09 Apr 2016 and first published on 13 Apr 2016


Article type: Communication
DOI: 10.1039/C6CP00777E
Citation: Phys. Chem. Chem. Phys., 2016,18, 23458-23461
  •   Request permissions

    Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

    S. Gao, B. Hu, X. Zheng, D. Liu, M. Sun, J. Qin, H. Zhou, B. Jiao and L. Wang, Phys. Chem. Chem. Phys., 2016, 18, 23458
    DOI: 10.1039/C6CP00777E

Search articles by author

Spotlight

Advertisements