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Issue 6, 2017
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Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

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Abstract

DNA aptamers that enhance calcium phosphate mineral formation were identified using a novel precipitation SELEX method. The evolved DNA library was substantially enriched in G nucleotides and in predicted G-quadruplex structures, suggesting their importance in the mechanism of mineralization. This work could readily be extended to provide additional novel DNA aptamers for materials synthesis.

Graphical abstract: Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

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Publication details

The article was received on 31 Oct 2016, accepted on 22 Dec 2016 and first published on 22 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC08687J
Citation: Chem. Commun., 2017,53, 1092-1095
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    Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

    K. R. Baillargeon, K. Meserve, S. Faulkner, S. Watson, H. Butts, P. Deighan and A. E. Gerdon, Chem. Commun., 2017, 53, 1092
    DOI: 10.1039/C6CC08687J

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