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Issue 2, 2017
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Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

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Abstract

Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.

Graphical abstract: Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

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Publication details

The article was received on 26 Oct 2016, accepted on 29 Nov 2016 and first published on 29 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08621G
Citation: Chem. Commun., 2017,53, 436-439
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    Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

    J. Kong, J. Zhu and U. F. Keyser, Chem. Commun., 2017, 53, 436
    DOI: 10.1039/C6CC08621G

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