A Shake&Read distance-based microfluidic chip as a portable quantitative readout device for highly sensitive point-of-care testing

Yi Xie; Xiaofeng Wei; Qizhen Yang; Zhichao Guan; Dan Liu; Xuan Liu; Leiji Zhou; Zhi Zhu; Zhenyu Lin; Chaoyong Yang

doi:10.1039/C6CC07928H

A Shake&Read distance-based microfluidic chip as a portable quantitative readout device for highly sensitive point-of-care testing†

Yi Xie,‡^a Xiaofeng Wei,‡^b Qizhen Yang,^c Zhichao Guan,^a Dan Liu,^a Xuan Liu,^a Leiji Zhou,^a Zhi Zhu,*^a Zhenyu Lin*^b and Chaoyong Yang*^a

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China
E-mail: cyyang@xmu.edu.cn, zhuzhi@xmu.edu.cn

^b MOE Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian, P. R. China
E-mail: zylin@fzu.edu.cn

^c Xiamen University Affiliated Keji High School, P. R. China

Abstract

Despite the rapid development of point-of-care testing (POCT) devices in recent years, quantitative POCT is still not readily available. Herein, we developed a simple, disposable and equipment-free quantitative POCT platform, the Shake&Read distance-based microfluidic Chip (S&R-μChip), for visual quantitative POCT and demonstrated its use in Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of disease biomarkers.

Chemical Communications

A Shake&Read distance-based microfluidic chip as a portable quantitative readout device for highly sensitive point-of-care testing†

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A Shake&Read distance-based microfluidic chip as a portable quantitative readout device for highly sensitive point-of-care testing

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