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Issue 89, 2016
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Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)–H bonds

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Abstract

An efficient and convenient method has been developed to achieve direct silylation of unactivated remote primary or secondary C(sp3)–H bonds to form C–Si bonds with hexamethyldisilane (HMDS). This method highlights the emerging strategy to transform unactivated methyl or methylene into versatile functional groups in organic synthesis and provides a new method to construct functionalized C–Si bonds for synthetic chemistry.

Graphical abstract: Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)–H bonds

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Publication details

The article was received on 28 Sep 2016, accepted on 10 Oct 2016 and first published on 11 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07885K
Citation: Chem. Commun., 2016,52, 13151-13154
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    Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)–H bonds

    J. Pan, Q. Li, T. Zhang, S. Hou, J. Kang and S. Zhang, Chem. Commun., 2016, 52, 13151
    DOI: 10.1039/C6CC07885K

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