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Issue 87, 2016
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Substrate scope for trimethyllysine hydroxylase catalysis

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Abstract

Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(II) and 2-oxoglutarate dependent oxygenase that catalyses the C-3 hydroxylation of an unactivated C–H bond in L-trimethyllysine in the first step of carnitine biosynthesis. The examination of trimethyllysine analogues as substrates for human TMLH reveals that the enzyme does hydroxylate substrates other than natural L-trimethyllysine.

Graphical abstract: Substrate scope for trimethyllysine hydroxylase catalysis

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Publication details

The article was received on 27 Sep 2016, accepted on 05 Oct 2016, published on 05 Oct 2016 and first published online on 05 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07845A
Citation: Chem. Commun., 2016,52, 12849-12852
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    Substrate scope for trimethyllysine hydroxylase catalysis

    A. H. K. Al Temimi, B. J. G. E. Pieters, Y. V. Reddy, P. B. White and J. Mecinović, Chem. Commun., 2016, 52, 12849
    DOI: 10.1039/C6CC07845A

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