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Issue 89, 2016
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Multifunctional single-layered vesicles derived from Cu(II)-metal–organic-polyhedra

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Abstract

Cu(II) metal–organic-polyhedra (MOP) derived from a tris-pyridyl ligand gave stable single-layered vesicles capable of encapsulating an anti-cancer drug (doxorubicin – DOX) and its pH responsive release. While encapsulation of DOX was further confirmed by MTT assay and cellular imaging, α-chymotrypsin inhibition assay corroborated well with the single crystal structures of the MOP. The MOP derived vesicles reported herein not only represent the rare examples of such hierarchical architectures derived from MOP but also provide the first example of multifunctional organic–inorganic synthetic bio-membranes.

Graphical abstract: Multifunctional single-layered vesicles derived from Cu(ii)-metal–organic-polyhedra

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Supplementary files

Publication details

The article was received on 26 Sep 2016, accepted on 13 Oct 2016 and first published on 13 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07804D
Citation: Chem. Commun., 2016,52, 13124-13127
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    Multifunctional single-layered vesicles derived from Cu(II)-metal–organic-polyhedra

    K. Sarkar, M. Paul and P. Dastidar, Chem. Commun., 2016, 52, 13124
    DOI: 10.1039/C6CC07804D

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