Jump to main content
Jump to site search

Issue 90, 2016
Previous Article Next Article

Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents

Author affiliations

Abstract

A general method for the copper mediated nucleophilic 123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.

Graphical abstract: Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Sep 2016, accepted on 12 Oct 2016 and first published on 12 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07417K
Citation: Chem. Commun., 2016,52, 13277-13280
  •   Request permissions

    Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents

    T. C. Wilson, G. McSweeney, S. Preshlock, S. Verhoog, M. Tredwell, T. Cailly and V. Gouverneur, Chem. Commun., 2016, 52, 13277
    DOI: 10.1039/C6CC07417K

Search articles by author

Spotlight

Advertisements