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Issue 88, 2016
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Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

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Abstract

Stable 2-D metal–organic framework nanosheets were utilized as a superior clean-background matrix for MALDI-TOF MS analysis of small biomolecules and pollutants in both positive and negative ion modes. The matrix could unusually afford up to 1000 mM of the salt concentrations in the monitoring of the enzymatic hydrolysis of neurotransmitter acetylcholine.

Graphical abstract: Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

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Publication details

The article was received on 09 Sep 2016, accepted on 07 Oct 2016 and first published on 07 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07371A
Citation: Chem. Commun., 2016,52, 12984-12987
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    Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

    H. Liu, Y. Chang, T. Fan and Z. Gu, Chem. Commun., 2016, 52, 12984
    DOI: 10.1039/C6CC07371A

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