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Issue 88, 2016
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Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits

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Abstract

We report a new nucleic acid sensing strategy through an intelligent design of spatial organization based reciprocal switching of catalytic hairpin assembly (CHA). The so-called SORS-CHA not only turns a well-designed CHA circuit into a relatively universal detector for any targeting sequence, but also guarantees a much enhanced signal resolution and a believability to minimize the misreading induced by unexpected signal drifts. With more trustworthy results, but a simpler sequence design, nucleic acid circuits could become competitive in real-world applications.

Graphical abstract: Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits

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Publication details

The article was received on 01 Sep 2016, accepted on 10 Oct 2016 and first published on 10 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07153H
Citation: Chem. Commun., 2016,52, 13043-13046
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    Spatial organization based reciprocal switching of enzyme-free nucleic acid circuits

    Y. Tang, Z. Zhu, B. Lu and B. Li, Chem. Commun., 2016, 52, 13043
    DOI: 10.1039/C6CC07153H

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