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Issue 90, 2016
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Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

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Abstract

Natural products are privileged scaffolds due to their high propensity to possess bioactivity. To expedite discovery of thiol-containing compounds, we devised a selective solid-supported reagent for their immobilization, followed by cleavage of a photocleavable linker to yield stable natural product conjugates for direct detection by mass spectrometry. Importantly, the natural products can also be tracelessly released to yield the native structures for chemical and biological evaluation.

Graphical abstract: Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

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Publication details

The article was received on 30 Aug 2016, accepted on 28 Sep 2016, published on 30 Sep 2016 and first published online on 30 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC07111B
Citation: Chem. Commun., 2016,52, 13229-13232
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    Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

    S. L. Capehart and E. E. Carlson, Chem. Commun., 2016, 52, 13229
    DOI: 10.1039/C6CC07111B

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