In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging

Abstract

Three fluorinated (¹⁹F or ¹⁸F) small molecules were evaluated as fluorescent or radiolabeled probes for Aβ deposits in the brain. In vivo near-infrared imaging suggested that probe 4c could efficiently distinguish between transgenic mice and wild-type controls. Furthermore, the in vivo Cerenkov luminescence imaging with [¹⁸F]4c showed modest differences between the two groups.