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Issue 86, 2016
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In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging

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Abstract

Three fluorinated (19F or 18F) small molecules were evaluated as fluorescent or radiolabeled probes for Aβ deposits in the brain. In vivo near-infrared imaging suggested that probe 4c could efficiently distinguish between transgenic mice and wild-type controls. Furthermore, the in vivo Cerenkov luminescence imaging with [18F]4c showed modest differences between the two groups.

Graphical abstract: In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging

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Publication details

The article was received on 26 Aug 2016, accepted on 28 Sep 2016 and first published on 30 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC06995A
Citation: Chem. Commun., 2016,52, 12745-12748
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    In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging

    H. Fu, C. Peng, Z. Liang, J. Dai, B. Liu and M. Cui, Chem. Commun., 2016, 52, 12745
    DOI: 10.1039/C6CC06995A

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