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Issue 86, 2016
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G-Quadruplex formation using fluorescent oligonucleotides as a detection method for discriminating AGG trinucleotide repeats

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Abstract

We have developed a simple and sensitive system for detecting AGG trinucleotide repeats through the formation of intermolecular G-quadruplexes using a fluorescent oligonucleotide. The fluorescence signal increased rapidly and dramatically by 44.7-fold with respect to the low background signal in the presence of RNA agg repeats and by 35.0-fold in the presence of DNA AGG repeats.

Graphical abstract: G-Quadruplex formation using fluorescent oligonucleotides as a detection method for discriminating AGG trinucleotide repeats

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Publication details

The article was received on 09 Aug 2016, accepted on 03 Oct 2016 and first published on 03 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC06566J
Citation: Chem. Commun., 2016,52, 12757-12760
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    G-Quadruplex formation using fluorescent oligonucleotides as a detection method for discriminating AGG trinucleotide repeats

    Y. Park, K. T. Kim and B. H. Kim, Chem. Commun., 2016, 52, 12757
    DOI: 10.1039/C6CC06566J

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