Jump to main content
Jump to site search

Issue 87, 2016
Previous Article Next Article

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors

Author affiliations

Abstract

Hsp90 C-terminal modulation represents an attractive strategy for the development of potent and safer antitumor compounds. Continuing our investigation on DHPM type inhibitors here we report a new set of potent C-terminal ligands which allowed us to identify the key structural features crucial for the biological activity.

Graphical abstract: Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 02 Aug 2016, accepted on 05 Oct 2016 and first published on 05 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC06379A
Citation: Chem. Commun., 2016,52, 12857-12860
  •   Request permissions

    Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors

    S. Teracciano, M. G. Chini, M. C. Vaccaro, M. Strocchia, A. Foglia, A. Vassallo, C. Saturnino, R. Riccio, G. Bifulco and I. Bruno, Chem. Commun., 2016, 52, 12857
    DOI: 10.1039/C6CC06379A

Search articles by author