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Issue 90, 2016
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C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams

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Abstract

Pd-catalyzed selective amine-oriented C8–H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing group for promoting this process. It represents a straightforward and easy method to access various biologically important benzo[cd]indol-2(1H)-one derivatives.

Graphical abstract: C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams

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Publication details

The article was received on 03 Aug 2016, accepted on 12 Oct 2016 and first published on 17 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC06358F
Citation: Chem. Commun., 2016,52, 13307-13310
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    C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams

    R. Shi, L. Lu, H. Xie, J. Yan, T. Xu, H. Zhang, X. Qi, Y. Lan and A. Lei, Chem. Commun., 2016, 52, 13307
    DOI: 10.1039/C6CC06358F

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