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Issue 82, 2016
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Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

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Abstract

Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

Graphical abstract: Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

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Publication details

The article was received on 21 Jul 2016, accepted on 14 Sep 2016 and first published on 14 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC06024B
Citation: Chem. Commun., 2016,52, 12155-12158
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    Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

    K. Zhou, P. Kos, Y. Yan, H. Xiong, Y. Min, K. A. Kinghorn, J. T. Minnig, J. B. Miller and D. J. Siegwart, Chem. Commun., 2016, 52, 12155
    DOI: 10.1039/C6CC06024B

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