Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

Naatasha Isahak; Guillaume Gody; Lara R. Malins; Nicholas J. Mitchell; Richard J. Payne; Sébastien Perrier

doi:10.1039/C6CC06010B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation†

Naatasha Isahak,^a Guillaume Gody,^b Lara R. Malins,^a Nicholas J. Mitchell,^a Richard J. Payne*^a and Sébastien Perrier

*^abc

Author affiliations

* Corresponding authors

^a School of Chemistry, The University of Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au

^b Department of Chemistry, The University of Warwick, Coventry, UK
E-mail: s.perrier@warwick.ac.uk

^c Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Australia

Abstract

A novel method for the introduction of a single protected amine-functional monomer at the chain end of RAFT polymers has been developed. This monomer addition, in concert with native chemical ligation, facilitated the development of a simple and versatile method for the end-functionalization of polymers with peptides.

Download options Please wait...

Supplementary files

Supplementary information PDF (1656K)

Article information

DOI: https://doi.org/10.1039/C6CC06010B
Article type: Communication
Submitted: 21 Jul 2016
Accepted: 21 Sep 2016
First published: 23 Sep 2016

Download Citation

Chem. Commun., 2016,52, 12952-12955

Permissions

Request permissions

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

N. Isahak, G. Gody, L. R. Malins, N. J. Mitchell, R. J. Payne and S. Perrier, Chem. Commun., 2016, 52, 12952 DOI: 10.1039/C6CC06010B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

Social activity

Search articles by author

Spotlight

Advertisements