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Issue 90, 2016
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Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor

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Abstract

Molecular rotors have emerged as versatile probes of microscopic viscosity in lipid bilayers, although it has proved difficult to find probes that stain both phases equally in phase-separated bilayers. Here, we investigate the use of a membrane-targeting viscosity-sensitive fluorophore based on a thiophene moiety with equal affinity for ordered and disordered lipid domains to probe ordering and viscosity within artificial lipid bilayers and live cell plasma membranes.

Graphical abstract: Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor

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Publication details

The article was received on 19 Jul 2016, accepted on 06 Oct 2016 and first published on 07 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC05954F
Citation: Chem. Commun., 2016,52, 13269-13272
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    Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor

    M. R. Dent, I. López-Duarte, C. J. Dickson, P. Chairatana, H. L. Anderson, I. R. Gould, D. Wylie, A. Vyšniauskas, N. J. Brooks and M. K. Kuimova, Chem. Commun., 2016, 52, 13269
    DOI: 10.1039/C6CC05954F

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