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Issue 80, 2016
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Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

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Abstract

N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related β-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.

Graphical abstract: Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

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Publication details

The article was received on 14 Jul 2016, accepted on 25 Aug 2016 and first published on 31 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC05807H
Citation: Chem. Commun., 2016,52, 11971-11974
  • Open access: Creative Commons BY-NC license
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    Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

    W. Zhao, N. Lorenz, K. Jung and S. A. Sieber, Chem. Commun., 2016, 52, 11971
    DOI: 10.1039/C6CC05807H

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