Jump to main content
Jump to site search

Issue 79, 2016
Previous Article Next Article

Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

Author affiliations

Abstract

Metal exchange is a common strategy to replace the zinc ion of many zinc proteins with other transition metals amenable to spectroscopic investigations. We here demonstrate that in anthrax lethal factor (and likely other zinc proteases), metal exchange is a fast process, and involves the occupation of an inhibitory metal site by the incoming ion prior to the release of zinc.

Graphical abstract: Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Jun 2016, accepted on 08 Aug 2016 and first published on 08 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC05460A
Citation: Chem. Commun., 2016,52, 11748-11751
  •   Request permissions

    Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

    C. J. Young and S. Siemann, Chem. Commun., 2016, 52, 11748
    DOI: 10.1039/C6CC05460A

Search articles by author

Spotlight

Advertisements