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Issue 93, 2016
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An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

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Abstract

An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein–polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.

Graphical abstract: An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

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Publication details

The article was received on 18 Jun 2016, accepted on 16 Sep 2016 and first published on 28 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC05099A
Citation: Chem. Commun., 2016,52, 13608-13611
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    An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

    J. Li, L. Zhang, Y. Liu, J. Wen, D. Wu, D. Xu, T. Segura, J. Jin, Y. Lu and H. Wang, Chem. Commun., 2016, 52, 13608
    DOI: 10.1039/C6CC05099A

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