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Issue 72, 2016
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DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

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Abstract

We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.

Graphical abstract: DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

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Publication details

The article was received on 14 Jun 2016, accepted on 07 Aug 2016 and first published on 09 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC04970B
Citation: Chem. Commun., 2016,52, 10914-10917
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    DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

    T. Trinh, P. Chidchob, H. S. Bazzi and H. F. Sleiman, Chem. Commun., 2016, 52, 10914
    DOI: 10.1039/C6CC04970B

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