Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(II) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

Erin Wachter; Ana Zamora; David K. Heidary; José Ruiz; Edith C. Glazer

doi:10.1039/C6CC04813G

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Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl₂(NH₃)₂]†

Erin Wachter,‡^a Ana Zamora,‡^b David K. Heidary,^a José Ruiz^b and Edith C. Glazer*^a

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* Corresponding authors

^a Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
E-mail: ec.glazer@uky.edu
Fax: +1-859-323-1069
Tel: +1-859-257-2198

^b Departamento de Química Inorgánica and Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30771 Murcia, Spain

Abstract

Two thermally activated ruthenium(II) polypyridyl complexes, cis-Ru(bpy)₂Cl₂ and trans-Ru(qpy)Cl₂ were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl₂ was 7.1–9.5× more cytotoxic than cis-Ru(bpy)₂Cl₂. This discovery could open up a new area of metal-based chemotherapeutic research.

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Article information

DOI: https://doi.org/10.1039/C6CC04813G
Article type: Communication
Submitted: 08 Jun 2016
Accepted: 21 Jun 2016
First published: 23 Jun 2016

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Chem. Commun., 2016,52, 10121-10124

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Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(II) polypyridyl complexes from cis/trans-[PtCl₂(NH₃)₂]

E. Wachter, A. Zamora, D. K. Heidary, J. Ruiz and E. C. Glazer, Chem. Commun., 2016, 52, 10121 DOI: 10.1039/C6CC04813G

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