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Issue 60, 2016
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Immobilization of an artificial imine reductase within silica nanoparticles improves its performance

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Abstract

Silica nanoparticles equipped with an artificial imine reductase display remarkable activity towards cyclic imine- and NAD+ reduction. The method, based on immobilization and protection of streptavidin on silica nanoparticles, shields the biotinylated metal cofactor against deactivation yielding over 46 000 turnovers in pure samples and 4000 turnovers in crude cellular extracts.

Graphical abstract: Immobilization of an artificial imine reductase within silica nanoparticles improves its performance

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Publication details

The article was received on 01 Jun 2016, accepted on 28 Jun 2016 and first published on 06 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC04604E
Citation: Chem. Commun., 2016,52, 9462-9465
  • Open access: Creative Commons BY license
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    Immobilization of an artificial imine reductase within silica nanoparticles improves its performance

    M. Hestericová, M. R. Correro, M. Lenz, P. F.-X. Corvini, P. Shahgaldian and T. R. Ward, Chem. Commun., 2016, 52, 9462
    DOI: 10.1039/C6CC04604E

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