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Issue 70, 2016
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Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines

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Abstract

The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of α-substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported.

Graphical abstract: Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines

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Publication details

The article was received on 16 May 2016, accepted on 01 Aug 2016 and first published on 01 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC04132A
Citation: Chem. Commun., 2016,52, 10632-10635
  • Open access: Creative Commons BY license
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    Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines

    R. de la Campa, A. D. Gammack Yamagata, I. Ortín, A. Franchino, A. L. Thompson, B. Odell and D. J. Dixon, Chem. Commun., 2016, 52, 10632
    DOI: 10.1039/C6CC04132A

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