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Issue 59, 2016
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Active tumor-targeting luminescent gold clusters with efficient urinary excretion

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Abstract

We present novel active targeting luminescent gold nanoclusters (AuNCs), which are prepared through a one-pot procedure by using a pentapeptide (CRGDS) for stabilization and tumor recognition. CRGDS–AuNCs exhibit a high tumor-specific retention with an exceptionally high tumor-to-liver uptake ratio of 9.3. Their small hydrodynamic diameter and zwitterionic surface facilitate urinary excretion, which reaches 82% within 24 h after injection.

Graphical abstract: Active tumor-targeting luminescent gold clusters with efficient urinary excretion

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Publication details

The article was received on 06 May 2016, accepted on 17 Jun 2016 and first published on 17 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC03814J
Citation: Chem. Commun., 2016,52, 9232-9235
  • Open access: Creative Commons BY license
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    Active tumor-targeting luminescent gold clusters with efficient urinary excretion

    X. Wang, H. He, Y. Wang, J. Wang, X. Sun, H. Xu, W. M. Nau, X. Zhang and F. Huang, Chem. Commun., 2016, 52, 9232
    DOI: 10.1039/C6CC03814J

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