Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation

Hikaru Yanai; Nobuyuki Ishii; Takashi Matsumoto

doi:10.1039/C6CC03510H

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Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation†

Hikaru Yanai,*^a Nobuyuki Ishii^a and Takashi Matsumoto*^a

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* Corresponding authors

^a School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
E-mail: yanai@toyaku.ac.jp, tmatsumo@toyaku.ac.jp

Abstract

1,2,3,4-Tetrasubstituted naphthalenes bearing four different substituents were synthesized in a regioselective manner through a fluoride-induced cascade reaction of lactol silyl ethers, which could be easily prepared from 4-alkynylisocoumarins and ketene silyl acetal.

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Article information

DOI: https://doi.org/10.1039/C6CC03510H
Article type: Communication
Submitted: 27 Apr 2016
Accepted: 23 May 2016
First published: 23 May 2016

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Chem. Commun., 2016,52, 7974-7977

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Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation

H. Yanai, N. Ishii and T. Matsumoto, Chem. Commun., 2016, 52, 7974 DOI: 10.1039/C6CC03510H

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Chemical Communications

Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation†

Abstract

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Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation

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