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Issue 54, 2016
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Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

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Abstract

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18F]KF/K222 in the presence of Cu(OTf)2py4. The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of 18F-fluoride.

Graphical abstract: Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

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Publication details

The article was received on 19 Apr 2016, accepted on 23 May 2016 and first published on 23 May 2016


Article type: Communication
DOI: 10.1039/C6CC03295H
Citation: Chem. Commun., 2016,52, 8361-8364
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    Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

    S. Preshlock, S. Calderwood, S. Verhoog, M. Tredwell, M. Huiban, A. Hienzsch, S. Gruber, T. C. Wilson, N. J. Taylor, T. Cailly, M. Schedler, T. L. Collier, J. Passchier, R. Smits, J. Mollitor, A. Hoepping, M. Mueller, C. Genicot, J. Mercier and V. Gouverneur, Chem. Commun., 2016, 52, 8361
    DOI: 10.1039/C6CC03295H

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