Issue 51, 2016
From the journal:

Chemical Communications

Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging†

Ruijiao Dong,‡ab   Screenath P. Ravinathan,‡c   Lizhe Xue,d   Nan Li,*a   Yingjian Zhang,a   Linzhu Zhou,b   Chengxi Caoe  and  Xinyuan Zhu*b  

* Corresponding authors

a Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
E-mail: linan466@163.com

b School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
E-mail: xyzhu@sjtu.edu.cn
Tel: +86-21-54746215

c School of Chemical Sciences, Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Priyadarshini Hills P. O., Kottayam, Kerala, India

d Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China

e School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China

Abstract

Dual-responsive aggregation-induced emission-active supramolecular fluorescent nanoparticles are reported, which have the ability to undergo a unique morphological transition combining with a cooperative optical variation in response to pH and light stimuli. The dynamic supramolecular nanoparticles show excellent biocompatibility and effective plasmid DNA condensation capability, further achieving efficient in vitro gene delivery and bioimaging.

Graphical abstract: Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging

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Article information

DOI
https://doi.org/10.1039/C6CC02794F
Article type
Communication
Submitted
03 Apr 2016
Accepted
23 May 2016
First published
23 May 2016

Chem. Commun., 2016,52, 7950-7953

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Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging

R. Dong, S. P. Ravinathan, L. Xue, N. Li, Y. Zhang, L. Zhou, C. Cao and X. Zhu, Chem. Commun., 2016, 52, 7950 DOI: 10.1039/C6CC02794F

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