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Issue 47, 2016
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Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

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Abstract

Solution-state NMR spectroscopy remains the primary method for characterising synthetic supramolecular assemblies. Yet, in their NMR spectra, relaxation interference effects can significantly alter peak intensities hindering interpretation. Here, we present a simple experiment for synthetic chemists to analyse this effect, allowing interpretation of these distorted spectra and validation of spectral assignments. We apply this experiment to synthetic porphyrin oligomers with molecular weights approaching those of protein domains (10 kDa). Our experiment provides a simple means to gain additional structural and dynamical information that will become increasingly useful as chemists create larger molecular architectures.

Graphical abstract: Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

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Publication details

The article was received on 24 Mar 2016, accepted on 15 Apr 2016 and first published on 15 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC02544G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 7450-7453
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    Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

    G. Karunanithy, A. Cnossen, H. Müller, M. D. Peeks, N. H. Rees, T. D. W. Claridge, H. L. Anderson and A. J. Baldwin, Chem. Commun., 2016, 52, 7450
    DOI: 10.1039/C6CC02544G

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