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Issue 51, 2016
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Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing

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Abstract

RNA editing from adenosine to inosine (A-to-I editing) is one of the mechanisms that regulate and diversify the transcriptome. Here, a triplex-forming peptide nucleic acid (PNA) modified with a 2-aminopyridine nucleobase was applied for the recognition of the A-to-I editing event in double-stranded RNAs. The triplex-forming PNA enabled sequence-specific detection of single nucleobase editing at sub-nanomolar concentration.

Graphical abstract: Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing

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Publication details

The article was received on 11 Mar 2016, accepted on 27 Apr 2016 and first published on 27 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC02164F
Citation: Chem. Commun., 2016,52, 7935-7938
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    Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing

    C. Annoni, T. Endoh, D. Hnedzko, E. Rozners and N. Sugimoto, Chem. Commun., 2016, 52, 7935
    DOI: 10.1039/C6CC02164F

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