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Issue 47, 2016
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β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

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Abstract

Peptides containing β-amino acids are unique non-natural polymers known to assemble into protein-like tertiary and quaternary structures. When composed solely of β-amino acids, the structures formed, defined assemblies of 14-helices called β-peptide bundles, fold cooperatively in water solvent into unique and discrete quaternary assemblies that are highly thermostable, bind complex substrates and metal ion cofactors, and, in certain cases, catalyze chemical reactions. In this Perspective, we recount the design and elaboration of β-peptide bundles and provide an outlook on recent, unexpected discoveries that could influence research on β-peptides and β-peptide bundles (and β-amino acid-containing proteins) for decades to come.

Graphical abstract: β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

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Publication details

The article was received on 19 Feb 2016, accepted on 21 Apr 2016, published on 05 May 2016 and first published online on 05 May 2016


Article type: Feature Article
DOI: 10.1039/C6CC01546H
Citation: Chem. Commun., 2016,52, 7420-7432
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    β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

    P. S. P. Wang and A. Schepartz, Chem. Commun., 2016, 52, 7420
    DOI: 10.1039/C6CC01546H

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