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Issue 46, 2016
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Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

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Abstract

A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent “templating” approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

Graphical abstract: Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

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Publication details

The article was received on 01 Feb 2016, accepted on 19 Feb 2016 and first published on 19 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC01032F
Citation: Chem. Commun., 2016,52, 7368-7371
  • Open access: Creative Commons BY license
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    Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

    L. R. Agnew, D. L. Cruickshank, T. McGlone and C. C. Wilson, Chem. Commun., 2016, 52, 7368
    DOI: 10.1039/C6CC01032F

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