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Issue 46, 2016
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Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

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Abstract

A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

Graphical abstract: Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

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Publication details

The article was received on 01 Feb 2016, accepted on 01 Apr 2016 and first published on 06 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC01027J
Citation: Chem. Commun., 2016,52, 7372-7375
  • Open access: Creative Commons BY license
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    Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

    L. H. Thomas, C. Wales and C. C. Wilson, Chem. Commun., 2016, 52, 7372
    DOI: 10.1039/C6CC01027J

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