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Issue 22, 2016
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Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

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Abstract

Two isomorphous cocrystals of nitazoxanide (NTZ) with p-aminosalicylic acid (PASA) and p-aminobenzoic acid (PABA) as well as their alloys were prepared by slurry and grinding techniques. The cocrystals exhibit faster dissolution rates and higher pharmacokinetic properties compared to the reference drug, and surprisingly the cocrystal alloy NTZ-PABA : NTZ-PASA (0.75 : 0.25) exhibited 4 fold higher bioavailability of NTZ in Sprague Dawley rats. This study opens the opportunity for cocrystal alloys as improved medicines.

Graphical abstract: Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

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Publication details

The article was received on 31 Jan 2016, accepted on 15 Feb 2016 and first published on 18 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC00975A
Citation: Chem. Commun., 2016,52, 4223-4226
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    Cocrystals and alloys of nitazoxanide: enhanced pharmacokinetics

    K. Suresh, M. K. C. Mannava and A. Nangia, Chem. Commun., 2016, 52, 4223
    DOI: 10.1039/C6CC00975A

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