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Issue 24, 2016
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Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

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Abstract

DSC and NMR results prove the existence of an amorphous acetaminophen nanolayer between acetaminophen nanocrystals (form I and form III) and pore walls in controlled porous glasses. This nanolayer controls the surface energy. This finding is highly relevant for approaches towards crystal engineering in nanopores and indicates similarities to the situation during the early stages of crystallization in polymorphic bulk samples.

Graphical abstract: Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

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Publication details

The article was received on 30 Jan 2016, accepted on 23 Feb 2016 and first published on 23 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC00962J
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 4466-4469
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    Pharmaceutical nanocrystals confined in porous host systems – interfacial effects and amorphous interphases

    N. Sonnenberger, N. Anders, Y. Golitsyn, M. Steinhart, D. Enke, K. Saalwächter and M. Beiner, Chem. Commun., 2016, 52, 4466
    DOI: 10.1039/C6CC00962J

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